Heart and Lung Health
This category contains analyses about heart and lung function in children born to mothers with HIV. We are interested in evaluating the safety of ARV treatment given to pregnant mothers with HIV on the heart and lung health of their children. This category has analyses about factors that might predict higher levels of biological signals of heart disease. It also looks at echocardiographic measures of heart function and structure, as well as lung function tests of children born to mothers with HIV.
Click to see an infographic of overall findings from the Cardiopulmonary Working Group.
Biomarkers of Heart Health in Children and Teenagers Living with Perinatal HIV
In the early 1990s, many children living with PHIV had serious heart problems. We wanted to see if there were any signs that HIV and ARVs had damaged the hearts of children and teenagers in the AMP study.
Asthma and Other Lung Problems in Youth Born with HIV
Some studies suggest that there may be a rise in asthma and lung problems in youth born with HIV. We wanted to see how well youth born with HIV are breathing by testing their lung function. We did pulmonary function tests (PFTs) on youth born with HIV using a breathing machine called a spirometer. PFTs measure how well the lungs are working.
Youth with HIV and Overall Risk for Heart Diseases
In this study, we created a scoring system based on weight, height, blood pressure, smoking, and fasting levels of sugar and fat in the blood. We used the scoring system to estimate changes to the blood vessels in the heart that can lead to heart diseases in infected youth born to mothers with HIV.
This publication was a collaboration between the Heart and Lung Health Working Group and the HIV Complications Working Group.
Heart Size and Health in HIV-positive Children Taking HAART
In this study of infected and uninfected youth born to mothers with HIV, we looked at the heart's size and shape in children who had taken combination antiretroviral medications (HAART) for many years.
Please note that this abstract was presented at the American Heart Association in Orlando, Florida, November 14-18, 2009.
Heart Health in Youth with HIV
In this study, we compared two groups: infected youth born to mothers with HIV who took HAART, and youth with HIV from the P2C2 study (most of whom did not take HAART). We used an echocardiogram (ultrasound) test to check the heart health of both groups of youth with HIV.
Asthma and Eczema in Youth with HIV
In this study, we looked at doctors' reports of infected and uninfected youth born to mothers with HIV to see if HIV or taking HIV medicines increased their risk for asthma and/or eczema.
Heart Health of Children Exposed to HIV
In this study, we tested the blood of children born to mothers with HIV. We tested the blood for three different chemicals to find out if there were signs that HIV and ARVs had affected the hearts of children born to mothers with HIV.
Other Publications about Heart and Lung Health
1. How highly active ARVs help improve heart function in people living with HIV
Fisher SD, Starc TJ, Guerra V, Williams PL, Wilkinson JD, Lipshultz SE. Declining incidence of systolic left ventricular dysfunction in HIV-infected individuals treated with highly active antiretroviral therapy. Am J Cardiol2016; 117(7):1194-95; PMCID: PMC4900683. http://www.ncbi.nlm.nih.gov/pubmed/26993978
2. Long-term heart health in PHEU youth exposed to ARVs in the womb
Guerra VC, Leister EC, Williams PL, Starc TJ, Lipshultz SE, Wilkinson J, Van Dyke R, Hazra R, Colan S. Long-term effects of in utero antiretroviral exposure: systolic and diastolic function in HIV-exposed uninfected youth. AIDS Res Hum Retroviruses 2016. 32(7):621-7; PMCID: PMC4931731 http://www.ncbi.nlm.nih.gov/pubmed/26794032
3. Long-term lung health in PHIV youth
Shearer WT, Jacobson DL, Yu W, Siberry GK, Purswani M, Siminski S, Butler L, Leister E, Scott G, Van Dyke RB, Yogev R, Paul ME, Puga A, Colin AA, and Kattan M for the Pediatric HIV/AIDS Cohort Study. Long-term pulmonary complications in perinatally HIV-infected youth. J Allergy Clin Immunol 2017; pii: S0091-6749(17)30336-6. PMCID: PMC 5587357. https://www.ncbi.nlm.nih.gov/pubmed/28279683
4. Biological markers of heart function and inflammation in PHIV and PHEU youth
Wilkinson JD, Williams PL, Yu Wendy, Colan SD, Mendez A, Zachariah JPV, VanDyke RB, Shearer WT, Margossian RE and Lipshultz SE for the Pediatric HIV/AIDS Cohort Study. Cardiac and inflammatory biomarkers in perinatally HIV-infected and HIV-exposed uninfected children. AIDS 2018 Jun 19,32(10):1267-1277. PMCID: PMC in process.https://www.ncbi.nlm.nih.gov/pubmed/29596110
5. Heart health in PHIV youth on combination ARV therapy: What do different studies show?
Williams PL, Correia K, Karalius B, Van Dyke RB, Wilkinson JD, Shearer WT, Colan SD, Lipshultz SE; Pediatric HIV/AIDS Cohort Study. Cardiac status of perinatally HIV-infected children: assessing combination antiretroviral regimens in observational studies. AIDS 2018 Aug 9. 32(16): 2337-2346.https://www.ncbi.nlm.nih.gov/pubmed/30102660
6. Heart health in PHEU youth exposed to ARVs in the womb
Lipshultz SE, Williams PL, Zeldow B, Wilkinson JD, Rich KC, Van Dyke RB, Seage GR III, Dooley LB, Kaltman JR, Siberry GK, Mofenson LM, Shearer WT, and Colan SD for the Pediatric HIV/AIDS Cohort Study. Cardiac effects of in utero exposure to antiretroviral therapy in HIV-uninfected children born to HIV-infected mothers. AIDS 2015; 29(1):91-100. PMCID: PMC4287991 http://www.ncbi.nlm.nih.gov/pubmed/25562493