This category contains analyses about factors and events that occur during pregnancy that may affect the baby. We are interested in seeing if pregnancy outcomes are associated with specific findings or events during pregnancy such as the use of specific ARV drugs, smoking or alcohol use, and severity of the mother’s HIV disease. From these studies, we will find out how frequently adverse outcomes occur. We will develop an understanding of why they happen so we can reduce their occurrence.
How Much Tenofovir Do Babies Absorb During Pregnancy?
Previous studies have only measured a baby's exposure to medicines at a single point in time using a blood test. Our study used a new approach of analyzing hair samples for measuring how much of the medicine tenofovir a baby had absorbed over the entire pregnancy.
ARVs and Early Birth in Women in SMARTT with Multiple Pregnancies
Previous studies suggest a connection between some HIV medications and risk of premature (early) birth. We wanted to see if among women with multiple pregnancies, there was a connection between babies being born premature, and use of newer medications, such as integrase inhibitors.
Hospital Visits and Infections in Young Children Born to Mother with HIV in the United States
Risk of Poor Pregnancy Outcomes for Three Antiretroviral Medicines
PROMISE was a clinical trial for pregant women with HIV. It took place in India and African countries. In part of PROMISE, women were treated with one of three different ARV regimens. Women on one of these regimens had babies born very prematurely (too early) or with very low birth weight compared to the other two regimens. We wanted to test the findings with our participants in the U.S.
Birth Weight and Early Delivery in Mothers Living with HIV
Changes in Blood Cells in Babies Born to Mothers with HIV
Tenofovir Use During Pregnancy and Bone Mineral Content in Babies
Mothers with HIV and Substance Use
Measuring a Baby's Exposure to HIV Medications
Testing how Well Babies Exposed to HIV Make Energy
In this study, we looked at uninfected babies of mothers with HIV to see if the HIV medicines some mothers took while pregnant affected how their babies make energy. To do this we used a finger stick test to measure lactate, a chemical in the blood. We also compared the results of the finger stick test to a more complicated blood test that is often used to measure lactate to see if the finger test was as accurate.
Please note that this abstract was presented at the Pediatric Academic Societies' Annual Meeting in Baltimore, Maryland on May 2 – 5, 2009.
Safety of Tenofovir Use During Pregnancy
Exposure to HIV Medication in HIV-Exposed but Uninfected Babies
In this study, we looked at uninfected children of mothers with HIV who took different types of antiretroviral medications (ARVs) during pregnancy. We looked at how ARV use during pregnancy by women with HIV has changed over time as well as factors linked to combination ARV regimen use during pregnancy.