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AMP Up Series

AMP

Between 2007 and 2009, the Adolescent Master Protocol (AMP) enrolled youth ages 7 -16 years who were born to mothers living with HIV.

AMP was designed to define the impact of HIV infection and antiretroviral therapy on youth living with perinatal HIV. This prospective cohort study enrolled three distinct groups:

  • 451 youth with perinatally acquired HIV (YPHIV)
  • A comparison cohort of 227 youth with perinatal HIV exposure but without perinatally acquired HIV (YPHEU)
  • 588 caregivers
 

AMP Up

The Adolescent Master Protocol (AMP Up) is an ongoing long-term study of young adults aged 18 years and older who were born to a mother living with HIV.

We plan to enroll 700 young adults living with perinatal HIV (PHIV) and 250 who were perinatally HIV-exposed but uninfected (PHEU). Eligible individuals include those previously enrolled in the AMP and SMARTT protocols as well as other perinatally-infected individuals. The study is designed to define the long-term outcomes of HIV infection and antiretroviral therapy (ART) among young adults with perinatal HIV infection as they age into adulthood. Data is being collected with a combination of online surveys, clinical assessments, interviews, and chart abstraction. The domain-specific AMP Up specific objectives are to:

  • Infectious Complications of HIV and Its Treatment
    Define the immunologic changes resulting from perinatal HIV infection and the infections that result from these changes.

  • Heart and Lung Disease
    To study the effects of HIV and antiretroviral medications on the function of the heart and the development of lung disease.

  • Metabolic Complications
    Study the effects of HIV and antiretroviral medications on body composition and metabolism and the risk of diabetes,  heart disease, and vascular disease. 
     
  • Sexually Transmitted Infections
    Evaluate access to testing and treatment of STIs, the frequency of these infections, and risk factors for acquiring them.
     
  • Reproductive Health
    Examine the frequency of pregnancy, use of birth control, the outcomes of pregnancy, and the use of methods to prevent the transmission of HIV to sexual partners and the newborn child.    

  • Neurocognitive Functioning and Mental Health
    Examine the short- and long-term consequences of exposure to or infection with HIV and its treatment on cognition, academic achievement, and on the neurological, emotional, and behavioral development of young adults. 
     
  • Health Care Behaviors, Quality of Life, and the Transition to Adult Health Care
    Describe predictors of adherence to ART and health care in young adults with PHIV, their quality of life, and their transition to adult health care. 
     
  • Risk Behaviors
    Examine the prevalence and predictors of sexual behaviors and use of licit and illicit substances in young adults with PHIV and PHEU. 
      
  • Hearing and Language
    Estimate the prevalence of language and hearing impairment in young adults, and their impact on educational attainment, psychosocial, and cognitive function, and employment outcomes. 

AMP Up Lite

In 2017, a less intensive version of AMP Up was created with similar objectives to those of AMP Up.  AMP Up Lite is limited to young adults with PHIV and has a planned enrollment of 500 participants.

 

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