Between 2007 and 2009, the Adolescent Master Protocol (AMP) enrolled youth ages 7 -16 years who were born to mothers living with HIV. This study was designed to define the impact of HIV infection and antiretroviral therapy on youth living with perinatal HIV. This prospective cohort study enrolled three distinct groups: Youth with perinatally acquired HIV (YPHIV), a comparison cohort of youth with perinatal HIV exposure but without perinatally acquired HIV (YPHEU), and caregivers.
The Adolescent Master Protocol for Participants 18 Years of Age and Older (AMP Up) was a long-term study of young adults aged 18 years and older who were born to mothers living with HIV. The study was designed to define the long-term outcomes of HIV infection and antiretroviral therapy (ART) among young adults with perinatal HIV infection as they age into adulthood. Data was collected with a combination of online surveys, clinical assessments, interviews, and chart abstraction.
The Adolescent Master Protocol Lite (AMP Up Lite) was a less intensive version of AMP Up with similar objectives to those of AMP Up. AMP Up Lite enrolled young adults living with HIV who were born to mothers living with HIV.
Protocol Chairs

Russ Van Dyke, MD
Professor of Clinical Pediatrics
Section Chief, Pediatrics Infectious Diseases
Tulane University School of Medicine

Katherine Tassiopoulos, DSc, MPH
Senior Research Scientist, Department of Epidemiology
Harvard T.H. Chan School of Public Health
DASH Datasets
Adolescent Master Protocol, PH200 (AMP)
The PHACS AMP study was designed to define the impact of HIV infection and antiretroviral therapy on pre-adolescents and adolescents with perinatal HIV infection. Domains investigated include growth and sexual maturation; metabolic risk factors for cardiovascular disease; cardiac function; bone health; neurologic, neurodevelopment, language, hearing, and behavioral function; and adolescent gynecology and HPV infection. Biospecimens are available.
Source Repository
DASH
Date Released
June 15, 2018
Date Updated
October 23, 2024
Adolescent Master Protocol for Participants 18 Years of Age and Older, PH300 (AMP Up)
This study investigated the long-term outcomes of perinatal HIV (PHIV) and its treatment on young adults with perinatally acquired HIV (YAPHIV). Young adults living with perinatal HIV exposure without perinatally acquired HIV (YAPHEU) were also enrolled. The primary objectives were to: 1) identify infectious and non-infectious complications of HIV disease and toxicities resulting from long-term ART; 2) define the impact of HIV infection and ART on the long-term clinical outcomes in YAPHIV; and 3) define the impact of perinatal HIV infection, its concomitant risk factors, and ART on long-term neurocognitive and behavioral health outcomes. Data collection included clinical assessments, online surveys, interviews, laboratory testing, specimen collection, and medical chart abstraction, designed to achieve the primary objectives and domain specific study aims. Results can be used to help design intervention strategies to improve the quality of life of young adults with perinatal HIV.
Source Repository
DASH
Date Released
July 8, 2025