Public Use Datasets
Surveillance Monitoring for ART Toxicities Study in HIV-uninfected Children Born to HIV-infected Women, PH100 (SMARTT)
The PHACS Surveillance Monitoring for ART Toxicities (SMARTT) Study was designed to identify potential adverse effects of ARV exposures in infants born to women with HIV infection, and to evaluate associations with ARV combinations and specific ARV drugs in order to help inform treatment guidelines for HIV-infected pregnant women. SMARTT follows two cohorts of HIV- and ART-exposed but uninfected children: the Static and Dynamic cohorts. Domains of interest include birth outcomes, growth, metabolic, cardiac, neurological, neurodevelopmental, behavior, language, and hearing. Biospecimens are available.
Source Repository
DASH
Date Released
April 5, 2019
Adolescent Master Protocol, PH200 (AMP)
The PHACS AMP study was designed to define the impact of HIV infection and antiretroviral therapy on pre-adolescents and adolescents with perinatal HIV infection. Domains investigated include growth and sexual maturation; metabolic risk factors for cardiovascular disease; cardiac function; bone health; neurologic, neurodevelopment, language, hearing, and behavioral function; and adolescent gynecology and HPV infection. Biospecimens are available.
Source Repository
DASH
Date Released
June 15, 2018
Date Updated
October 23, 2024
Adolescent Master Protocol for Participants 18 Years of Age and Older, PH300 (AMP Up)
This study investigated the long-term outcomes of perinatal HIV (PHIV) and its treatment on young adults with perinatally acquired HIV (YAPHIV). Young adults living with perinatal HIV exposure without perinatally acquired HIV (YAPHEU) were also enrolled. The primary objectives were to: 1) identify infectious and non-infectious complications of HIV disease and toxicities resulting from long-term ART; 2) define the impact of HIV infection and ART on the long-term clinical outcomes in YAPHIV; and 3) define the impact of perinatal HIV infection, its concomitant risk factors, and ART on long-term neurocognitive and behavioral health outcomes. Data collection included clinical assessments, online surveys, interviews, laboratory testing, specimen collection, and medical chart abstraction, designed to achieve the primary objectives and domain specific study aims. Results can be used to help design intervention strategies to improve the quality of life of young adults with perinatal HIV.
Source Repository
DASH
Date Released
July 8, 2025
Adolescent Master Protocol for Participants 18 Years of Age and Older – Lite, PH400 (AMP Up Lite)
This study investigated the long-term outcomes of perinatal HIV (PHIV) and its treatment on young adults with perinatally acquired HIV (YAPHIV). The primary objectives were to: 1) identify infectious and non-infectious complications of HIV disease and toxicities resulting from long-term ART; 2) define the impact of HIV infection and ART on the long-term clinical outcomes in YAPHIV; and 3) define the impact of perinatal HIV infection, its concomitant risk factors, and ART on long-term mental and behavioral health outcomes. Data collection included clinical assessments, online surveys, interviews, specimen collection, and medical chart abstraction, designed to achieve the primary objectives, as well as the domain specific study aims. Results can be used to help design intervention strategies to improve the quality of life of young adults with perinatal HIV.
Source Repository
DASH
Date Released
August 11, 2025
Health Outcomes around Pregnancy and Exposure to HIV/ARVs (HOPE)
The Health Outcomes around Pregnancy and Exposure to HIV/ARVs (HOPE) study investigated physical and mental health outcomes and health related behaviors of women living with HIV of reproductive age, including women living with HIV since birth. Health outcomes include HIV disease course, engagement in care, mental health, pregnancy, reproductive health and choices, and cardiometabolic health as well as multi-level social and structural determinants of health and sources of resilience. The framework was informed by a social ecological model, life course perspective, and community engagement. Data collection consists of clinical assessments, online surveys, health interviews, collection of specimens and medical chart abstraction designed to achieve the primary objectives and domain specific aims of the study, as outlined in the protocol. Results from HOPE aim to advance the health of women living with HIV, inform clinical guidelines and shape supportive interventions and policies that address the needs and priorities of women living with HIV and their families.
Source Repository
DASH
Date Released
May 5, 2025